| Food & Diet

Is Pterostilbene Better Than Resveratrol?

By Tyler Woodward

Pterostilbene is a natural compound found in a wide variety of foods, but is found in the highest concentrations in foods such as blueberries. Pterostilbene is known for its potent antioxidant and antiinflammatory properties and its similarities to the chemical resveratrol.

Although pterostilbene is often compared to resveratrol, it’s likely much more effective. Resveratrol has been cited to be a more potent antioxidant in certain studies, but resveratrol’s bioavailability is estimated to be 60% less than pterostilbene meaning only a fraction of resveratrol is actually absorbed in our body. Learn More: Not All Vitamins Are Created Equal | What Is Bioavailability?

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Benefits Of Pterostilbene:

Benefits Of Pterostilbene

While there’s not currently a lot of human research on pterostilbene it looks as though there are a number of promising benefits and effects from pterostilbene supplementation. 

  • Pterostilbene is a potent antioxidant - Ptersostilbene is known to be a free radical scavenger, helping to stop the chain reactions that free radicals cause which result in oxidative stress. By breaking this chain reaction through its antioxidant properties pterostilbene is able to exert a number of potent effects in the body.
  • Pterostilbene is very antiinflammatory - Likely through its effects as an antioxidant, pterostilbene has been shown to reduce the formation of inflammatory cytokines in the body. Cytokines are a type of protein secreted by the immune system in order to combat viral or bacterial “intruders” in the body in addition to communicating between both immune and non-immune cells to coordinate a unified response to a stress. While cytokines are necessary for the body to function in excess they can be extremely harmful and result in inflammation. Pterostilbene has been shown to reduce the production of a number of pro-inflammatory cytokines including TNF-𝞪, IL-5, IL-1β, IL-6. This also resulted in a reduction in inflammatory byproducts like malondialdehyde which results from the peroxidation of polyunsaturated fats and is often used as a marker for oxidative stress. Pterostilbene may also help fight endotoxin from exerting inflammatory effects.  
  • Ptersostilbene may fight atherosclerosis -The progression of heart disease is believed to be caused by an excess of oxidative stress from the accumulation of reactive oxygen species in the cell. Due to pterostilbene itself being an antioxidant it has been shown to help reduce the stress on the cardiovascular tissues. Additionally, pterostilbene has been shown to upregulate the cell’s production of antioxidants in the cell including the superoxide dismutase enzymes and thioredoxin reductase.
  • Pterostilbene may fight against cancer - A few studies have found that pterostilbene is able to increase cellular apoptosis in cancer cells. Apoptosis means ‘programmed cell death’ and is a normal process that occurs in the body as cells age over time. One of the mutations that occurs in cancer cells is that they no longer naturally undergo apoptosis and begin to replicate uncontrollably.  By causing the cancer cell to undergo apoptosis it can help to prevent the proliferation or reproduction of the cancer cell. 

Read More: Apigenin, The Most Powerful Herb You've Never Heard Of?

How To Consume Pterostilbene:

How To Consume Pterostilbene

Pterostilbene can found naturally in a few foods including:

If you’re looking for a pterostilbene supplement just make sure to purchase from a reputable source that performs both heavy metal and purity testing.

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