| hormonal support research

The Ultimate Guide To Thyrite: Thyroid Support Supplement | UMZU

By Jayton Miller

The thyroid is known as the key regulator of the metabolism. When your thyroid is not functioning correctly, it can have secondary effects that can cascade throughout the entire body. Some secondary effects can include:

  • Constipation
  • Diarrhea
  • Poor circulation
  • Adrenal fatigue
  • Poor sleep
  • Hypogonadism
  • Brain fog
  • Low libido
  • Infertility
  • Poor bone density
  • Frequent urination
  • High cholesterol
  • Slow wound healing
  • Dry skin
  • Hair loss
  • Fatigue
  • irritability

The list can go on and on as the thyroid is intimately involved in every metabolic process that takes place in the body.

Contents:

Why Should You Take Thyrite?

why to take thyrite

(Preface - if you have gone through the thyroid optimization course we have inside of UMZUfit, you have already seen these next two sections, so feel free to breeze through them. However, if you have not taken that course, please read through these sections as they are critical for proper background information on the product.)

Thyrite supplies the thyroid with the raw materials it needs in strategic doses in order to function at its highest possible capacity. We have only put ingredients in this product that have been shown in clinical research to be effective at helping the thyroid function properly.

The thyroid is a butterfly shaped gland that sits right behind the Adam's apple on your neck. The two main thyroid hormones are called triiodothyronine and thyroxine. 

Thyroxine is the most abundant thyroid hormone in the body. This is the hormone that is produced in larger amounts by the thyroid and travels throughout the body to be taken in by cells. Once it reaches its destination in the body, it is acted upon by the deiodinase enzyme. 

This enzyme cleaves off an iodine molecule and turns thyroxine into triiodothyronine. Triiodothyronine is the more active form of the two main thyroid hormones and it acts as a regulator of energy use and production within the cell, among many other things. Triiodothyronine is extremely important for proper overall metabolic function and for our cells to function optimally. Triiodothyronine is said to be around four times more potent or “powerful” than its precursor, thyroxine. 

Triiodothyronine enters into the cells and finds its way into the nucleus of the cell. The nucleus holds the DNA of the cell. 

When triiodothyronine enters into the nucleus, it acts upon what is known as Thyroid Hormone Response Elements. This allows triiodothyronine to have control over the expression of the genes that have these elements. Some examples of the genes regulated by triiodothyronine are growth hormone, uncoupling protein, fatty acid synthetase, prolactin, TSH, etc..

One of the many challenges that people face when trying to overcome thyroid or low metabolic problems is the inability to convert thyroxine to triiodothyronine. 

Many doctors only use the measurements of Thyroid Stimulating Hormone (TSH) and free thyroxine to measure the activity of the thyroid. This is one of the least effective ways to measure metabolic function. Most people who experience low metabolic or hypothyroid symptoms will get these tests done by their doctor and have them come back “normal.” So the doctor will send them home as if they just wasted his/her time. 

What the doctor does not take into consideration is the fact that the patient might have an inability to convert thyroxine to triiodothyronine. Most of this conversion happens in the liver. Many doctors, when looking at the health of the thyroid, completely ignore the liver. Without this conversion, the thyroid hormone pathway will not work. In many cases, even hyperthyroid patients have this hindered ability. Sometimes thyroxine converts into triiodothyronine, however, that triiodothyronine is “reversed”, also known as r-triiodothyronine. 

On a lab measuring triiodothyronine, the values may appear normal, however, the body’s cells cannot use this form of triiodothyronine as it is basically a blocking mechanism in the cell the backs up the pathway. Like the wrong key in a lock, it simply cannot stimulate the metabolism. It goes undiagnosed because it looks “normal” to the unknowing physician. The patients are then given thyroxine to treat the symptoms, but rather than helping, it is just clouding the pathway even more with the rather inactive hormone thyroxine. This is the equivalent of painting over rust - it never really fixes the underlying imbalance.

Read More: The Low Cortisol Lifestyle: UMZU's Guide To Fighting Stress

thyrite

Why does our thyroid stop working properly?

why the thyroid stops working

Why does our thyroid stop working properly when we need it to be firing on all cylinders? The answer is stress. 

Stress comes in many different forms, whether you are aware of them or not. Stress is not just psychological. It is not just the pressure put on you from work, the nagging of your husband/wife, or the weight of exams coming your way. This type of stress is important and can be just as detrimental as any other kind of stress. Making sure that we mitigate this kind of stress will be a key part in the healing process. 

Stress, however, can occur from almost anything. We define stress as anything that knocks the body out of balance. This lack of balance causes the stress hormones cortisol, adrenaline, aldosterone,estradiol, prolactin, and others to rise. When these hormones rise, we see a direct decrease in the protective hormones such as thyroid hormones, testosterone, growth hormone, progesterone, and dihydrotestosterone among others. Dietary stress is by far the biggest stressor behind physiological stress that begins to take a toll on the thyroid. 

With the Standard American Diet (SAD), we are very deficient in many micronutrients (vitamins and minerals). These are the raw materials our body uses to sustain itself. When we live without proper amounts of necessary micronutrients and consume an excess of toxins and foods that deplete us, we create an imbalance within the entire system of the body. As a result of this imbalance, the body’s stress hormones rise dramatically. When we factor in the near constant consumption of polyunsaturated fats and poor quality food full of hormones,chemicals, and heavy metals, we have a remedy for disaster. If this is you, it is not your fault. But, in order to fully heal, we have to start doing something about it. A poor diet directly increases all types of inflammation, which is the root cause of most, if not all, chronic illnesses and degenerative conditions. 

Physical stress is another common one that many people seem to overlook. There are two extremes that can really affect physical stress. The complete lack of activity and the excess of activity leading to catabolism (breakdown). 

Movement is necessary for optimal health. In order to express health and to express our positive epigenetic potential, we must be moving and moving well. Even if it is as little as walking for 30 minutes a day, it is crucial to get some form of movement into your daily routine. There are many systems in the body that require movement of the body. Movement kickstarts most of our body’s systems, all which work together like a beautiful symphony when we move. 

One of the systems that rely on movement the most is the lymphatic system. The lymphatic system is a circulatory system in the human body that helps to maintain fluid balance. The lymphatic system also helps to get rid of toxins in the body and fight infections via lymphocytes found in the lymph (liquid in the lymphatic system such as blood in the cardiovascular system). This system however does not have a “pump” like the cardiovascular system has the heart. The “pump” is our own movement, the movement of your body. 

If you do not move, the lymphatic system cannot function properly and we get a buildup of toxins within the system hindering proper metabolic function. Like a sewage backup, when we do not move, we get  a major backup of toxins and inflammatory debris stuck in our body. Our brain, the master control of our entire life experience, is literally fed by movement. Just as a wind turbine can generate electricity, moving our bodies generates healing by activating electrical activity in the brain. Other systems that need movement in order to function optimally include the digestive system, respiratory system, nervous system, and skeletal system.

Then, you have the other end of the spectrum. The ones who exercise too much and feel good initially, but over time slowly begin to break down and begin to feel worse despite their best efforts. If this is you then STOP! More is not always better, in fact, more can actually be worse than not doing enough. 

When it comes to physical exercise and other forms of exertion, the minimum effective dose is the most effective dose, especially when healing from a low metabolic state. By doing just enough to trigger the positive adaptation from exercise, you can experience all of the benefits that exercise has to offer. When you begin to do too much, several issues arise. You begin to cause an excess of stress hormones to consistently be in the body. This massive surge in stress hormones from exercise (yes exercise is a stress on the body) causes a blunting effect on the protective hormones. 

This completely defeats the purpose of exercising as you need protective hormones to heal and adapt positively from that exercise. Having chronically high stress levels is extremely catabolic and over time begins to break the body down. When you then continue to workout in this stressed state, your body gets broken down even more, and even faster. Over time, you are going to drive yourself straight into the ground, and maybe even a grave. So how do you workout in a way that is going to benefit you instead of hinder you? Keep reading to find out!

Emotional and mental stress is of critical importance. According to research from Dr. Martin Seligman, PhD, we have approximately 60-80,000 thoughts per day. For the average person 80% of these are negative. Furthermore, 95% of these thoughts are the same as yesterday. Each stressful thought triggers a chemical cascade, which results in your body becoming hardwired into stress. We literally think and feel our way into a chemically stressed body. This, in turn, hardwires our brain into a chronically stressed state. 

The final type of stress that has an impact on the health of your thyroid is environmental stress. From the air you breath to the water you drink to the light you are under all day, you are either helping or hurting your thyroid. What we drink has just as much impact as the food we eat. Especially when it comes to water. 

Many people overlook this, but drinking from plastic bottles and drinking unfiltered water has a direct impact on your thyroid. Tap water, especially in the U.S., is full of toxins from birth control to pesticides. Filtering your water or getting filtered water is going to make a huge difference. Avoiding plastics will allow you to avoid the estrogenic chemicals that they leach into the water that then make their way into your body, increasing stress and further decreasing the performance of the thyroid. 

While avoiding these things, we need to make sure we are getting proper light exposure. Our bodies were made to be outside. It is the way that we were originally designed and is still the way our body functions now. Getting at least 20 minutes of sunlight is a necessity. Most people in the society we live in today are not getting anywhere near this much sun exposure on a daily basis, and it is taking a toll on their health. Sunlight has many benefits. It helps control our natural sleep and wake cycle (circadian rhythm). It helps decrease the amount of negative neurotransmitters and increases positive ones to promote better mood and well being. It is very good for energy production as sunlight stimulates the activation of the mitochondria, ramping up energy production in the cell. 

Darkness is very catabolic to the body, and is why we sleep through the night. The wrong types of light can also be catabolic and increase stress on the body. One of these types of lights are the screen you are reading this on or look at in your hand each morning. This spectrum of light, known as blue light, is detrimental to the proper functioning of many processes that rely on light in the body to work optimally. The regulation of the thyroid being one of them. Instead, we need to ensure we are getting a broad spectrum of warming orange to red light. These are the healing spectrums of light that our bodies have adapted to throughout the thousands of years of human existence. 

Thyrite Ingredients

thyrite ingredients

As we have already mentioned, we have only included ingredients with clinical research supporting them. In our literature review, we found that the following are the most effective for improving your brain health and helping to eliminate stress.

  • Niacinamide
  • Iodine
  • Magnesium
  • Zinc
  • Selenium
  • Copper
  • Ashwagandha
  • Forskolin
  • L-Tyrosine
  • L-Taurine

All ten ingredients in Thyrite can aid your thyroid health by improving your body’s ability to fight stress.

Here is what each daily dose (four capsules) of Thyrite provides you with.

Ashwagandha (350 mg)

ashwagandha

Very few people are familiar with the ashwagandha herb, despite its well-documented benefits. 

In fact, its very name elicits a confused look. Among its many benefits, recent research revealed a strong ashwagandha testosterone connection. For men in their 30s and beyond, this is an herb that warrants your attention.

What Is Ashwagandha?

Ashwagandha is an herb rooted in Indian Ayurvedic medicine. In Sanskrit, the name translates to “the smell of a horse.” The name was chosen because the herb is reportedly so powerful that it can restore the vitality of an aging stallion. You may also hear ashwagandha referred to by its formal — and equally difficult-to-pronounce — name: withania somnifera.

The herb is traditionally taken as an adaptogen, meaning it helps the body relax in response to physical and emotional stressors. Its origin dates back to 5,000 years ago. Of course, the scientific research behind this potent tonic has only emerged in the past two decades or so. Nevertheless, the results validate the positive experiences felt by generations of people spanning from the days before Jesus and Buddha.

In centuries past and in modern times, people use ashwagandha for:

  • Strengthening their immune system
  • Insomnia
  • Constipation and diarrhea
  • Fatigue and lethargy
  • Joint inflammation
  • Intestinal parasites
  • Increasing testosterone

The Ashwagandha Testosterone Link

In one study, men who received an ashwagandha supplement had significantly higher testosterone levels compared to the placebo group after an eight-week trial. That is not all; subjects also engaged in strength training and had their performance and muscle mass gains measured. The ashwagandha group outperformed the placebo group in these following parameters:

  • Greater strength gains in bench presses and leg extensions
  • Increased muscle mass in the chest and arms
  • Greater reduction in exercise-induced muscle damage
  • Greater decrease in body fat percentage

This study is significant because not only did the trial show an increase in testosterone, but subjects also exhibited all the parameters associated with testosterone elevation.

Ashwagandha Lowers Cortisol

The ashwagandha-testosterone link may also be indirect. One study found that ashwagandha reduced cortisol levels by as much as 30 percent. As you may know, cortisol is the dreaded stress hormone. We even dedicated an entire post on lowering cortisol naturally because it is that detrimental for your testosterone levels and health in general. It ranks up there with inflammation as being a major health destroyer.

Ashwagandha Promotes Sleep

Another indirect pathway ashwagandha raises testosterone is by promoting sleep. A Japanese study from the University of Tsukuba found that the herb significantly improved non-rapid eye movement (NREM) sleep.

The importance of sleep is incredible. When you do not sleep well or only get a fraction of the recommended eight-hours, the effects are far more intense than a cranky morning. Your testosterone levels take a major dive. The inverse, by the way, is also true. Just as poor sleep causes low testosterone, low testosterone also leads to sleepless nights. It is a vicious cycle where one feeds off the other, resulting in an endless loop that goes on indefinitely until you take corrective action.

Ashwagandha Improves Sex Drive

Improved libido is one of the commonly reported positive effects of a testosterone boost. Another study confirmed that ashwagandha supplementation increased gonadotropin, a hormone needed for testosterone production. The gonadotropin also elevated levels of progesterone (a precursor of testosterone). Low progesterone levels have also been linked to diminished libido.

With all this talk on ashwagandha and testosterone, one would suspect the herb is mainly used for treating male problems. This is untrue, however. One study revealed ashwagandha was effective for treating female sexual dysfunction.

Where to Get Ashwagandha

It is unlikely that you will find ashwagandha in root or herbal form in western countries. This is where supplementation comes in. It is actually not uncommon to find ashwagandha as an active ingredient in natural testosterone supplements for men. In fact, it is a core ingredient in our own Testro-X. Of course, you will also find ashwagandha as a standalone supplement.

In any case, if you are seeking out this herb, we recommend looking for the designation KSM-66. This essentially means the product contains the highest concentration full-spectrum extract. In other words, it retains most of its constituents. It also has a withanolide concentration of 5 percent or higher. Withanolides refer to a class of over 300 naturally-occurring flavonoids, which contribute to many of ashwagandha’s benefits.

We recommend researching even further and determining the precise testing method. Try to verify if the withanolide content is tested using the trustworthy HPLC analysis. This produces far more accurate results over the less reliable and outdated gravimetric analysis. You do not need to understand precisely how each method works. Just know that gravimetric measurements can overestimate withanolide content by a factor as high as three.

Ashwagandha Is a Proven T-Boosting Herb

Ashwagandha certainly does not have the name recognition of more prominent herbs like ginseng, ginger or lavender. However, relative obscurity does not equate to ineffectiveness. The ashwagandha testosterone connection is very real. This is why we firmly stand behind this compound as one of the best, albeit unknown, natural testosterone supplements for men. 

If you are a woman, have no fear, this is not going to turn you into a man. Ashwagnadha by lowering stress will help naturally increase your protective hormones such as progesterone as well.

Learn More: 13 Benefits of Ashwagandha

Forskolin (250mg)

forskolin

Forskolin is a chemical compound that is derived from the plant Coleus forskohlii. For centuries, it has been used for medicinal purposes as a natural medicine, particularly in Asia, India, central Africa, and Brazil. More specifically, forskolin has been used as part of Ayurvedic medicine, an age-old type of healing practice that focuses on the whole body to achieve optimal health.

While the plant has been used in traditional medicine to treat several different health conditions, modern science has linked the use of forskolin to weight loss. As such, forskolin is commonly used as a weight loss supplement.

Other Names For Forskolin

Forskolin is also known as:

  • Indian Coleus
  • Borforsin
  • Coleus
  • Coleus Barbatus
  • Forskohlii

How Does Forskolin Work?

Forskolin activates an enzyme known as adenylate cyclase class III (AC-III), which plays a role in regulating all cells of the body. The main function of AC-III is to foster chemical messaging from outside to inside the body's cells, which is what helps forskolin promote its various benefits to the human body.

Benefits of Forskolin

There are several proposed benefits of forskolin supplementation, including the following.

Helps With Weight Loss

One of the more prominent uses of forskolin is for its effect on weight loss. Some research suggests that supplementing with forskolin may help users lose weight or maintain a healthy weight, though the studies are somewhat limited.

One small study assessed a group of overweight and obese men and found that the group who took 250mg of forskolin extract twice daily for 12 weeks lost more body fat compared to the group who took a placebo. That said, more research is needed to solidify these findings.

May Help to Treat Asthma

Forskolin has long been taken as a remedy for asthma, with some evidence supporting this position. Forskolin seems to work similarly to how certain traditional asthma medications work by increasing levels of cyclic AMP (cyclic adenosine monophosphate), a compound that helps to relax the muscles surrounding the bronchial tubes and makes it easier to breathe.

One study found that asthmatic children and adults who took forskolin supplements experienced a more significant reduction in the incidence of asthma attacks compared to when taking sodium cromoglycate, a common asthma drug.

May Protect Against Glaucoma

Some research suggests that forskolin applied to the eyes through drops or injections may help to protect against the onset of glaucoma, a condition that damages the eye's optic nerve and progressively worsens over time. Glaucoma is the leading cause of vision loss in adults.

One study found that supplementing with forskolin may help to reduce pressure of the inner eye by as much as 10 percent in patients with glaucoma after one month. More specifically, higher doses correlated with a greater reduction in eye pressure.

Another study found that forskolin eye drops may be able to decrease inner eye pressure in those with glaucoma after the same time period.

May Be Helpful in Treating Alzheimer’s Disease

While there is not much evidence to support the notion that forskolin may be able to help with Alzheimer’s treatment, a couple of studies are showing some promise.

One particular research paper discovered that rodents that took forskolin showed a reduction in several negative physical factors associated with Alzheimer’s disease, including reduced inflammatory activity and plaque in different parts of the brain.

How to Use Forskolin

Forskolin can be consumed in different formats. For starters, there are forskolin powders that can be mixed in beverages, as well as capsules. These tend to be the more common ways to use forskolin for purposes of losing weight.

Forskolin can also be prescribed as an inhaler by a physician if being used to treat asthma, or injected or dropped into the eye to treat glaucoma.

Recommended Forskolin Dosage

It is important to only access forskolin supplements from trusted manufacturers before using. In terms of appropriate dosing, it is recommended to follow the manufacturer's recommendations. Both the quality of the product and the dosing recommendations rely on the level of professionalism and reliability of the supplement manufacturer.

Generally speaking, the average dosage of forskolin is between 100mg to 250mg (10 percent forskolin) twice a day. If you are currently taking any medications, be sure to seek the advice of your physician before taking forskolin supplements.

Inhaled or intravenous forskolin can only be prescribed by a doctor. As such, the doses will be determined by your physician before being administered.

Supplementing With Forskolin

Forskolin is generally considered safe to use, though there could be certain side effects that may be possible from its consumption, including:

  • Rapid or irregular heartbeat
  • Lower blood pressure
  • Possible interaction with medications
  • Throat irritation
  • Cough
  • Restlessness
  • Stinging of the eye (from injections)
  • Potential increase of cyst size in women with polycystic ovarian syndrome (PCOS)

Is Forskolin Healthy?

Forskolin is a somewhat popular natural weight loss supplement, but its benefits in this area might not be as strong as they are touted to be. The supplement may also have other benefits aside from helping to achieve optimal weight, though further studies are needed to solidify such suggestions.

Magnesium (300mg)

magnesium

Some supplements are flashy; you hear about them all the time and about how they can be extremely helpful to your overall health. 

Magnesium usually is not one of these supplements, though. Instead, most people do not even know the role of magnesium plays in their bodies (and trust us, it has more than one!). 

However, magnesium supplements can be helpful to take, especially if your body is not already getting enough of it.

Details About Magnesium

Magnesium is a mineral that the body needs in order to be able to thrive and grow. It is involved in over 300 different biochemical reactions that occur naturally in the body, and it helps us with a number of essential functions, including those of our nerves, muscles, immune systems, bones, and heart. 

Magnesium makes sure our heart rhythm remains steady, our bones develop normally and we are able to produce the energy we need to get through the day suggests the Office of Dietary Supplements.

In addition, magnesium helps us control and break down glucose and synthesize DNA and RNA. It also helps to transport potassium and calcium across the membranes of our cells. Magnesium does so much for our bodies, but we hardly ever talk about it.

Magnesium Is Also Known As …

Magnesium is a chemical element that goes by the abbreviation Mg. Its atomic number is 12 on the Periodic Table. It is the eighth most abundant element in the world, and it can actually be found inside the earth’s crust. When we discuss magnesium as a supplement, we mostly will be focused on how it affects the body, but magnesium is a mineral that can be found almost anywhere.

Benefits of Taking Magnesium

It is important to always talk to a medical professional before taking a supplement, but many individuals are advised by their doctors to take a daily dose of magnesium in order to benefit their overall health. In fact, magnesium can reduce the risk of developing a number of serious and incredibly common conditions1. If you are at risk of any of the conditions below — or if you already have them and are looking for a possible supplemental treatment option — magnesium could be exactly what you need.

Heart Problems and High Blood Pressure

High blood pressure is one of the possible factors associated with other, more severe health problems. It is also one of the earliest warning signs of these issues. Fortunately, magnesium can help lower blood pressure in some individuals but usually only by a little bit (ODS). However, Harvard Medical School suggests that magnesium’s effect on the heart has more to do with maintaining its electrical properties, which can still help prevent cardiac problems — like sudden heart attacks — and death associated with them.

Osteoporosis

Between men and women, women are more likely to develop osteoporosis, a condition that affects bone density and strength, usually later in life. Taking magnesium supplements could be a possible way to stave off issues with osteoporosis.

Diabetes

Magnesium helps the body to better process glucose, which is part of the reason why those who have higher levels of magnesium in their bodies are less likely to develop type 2 diabetes.

Other Benefits of Magnesium

Not only can magnesium possibly prevent and treat these serious and common health conditions, but increasing magnesium intakes may also help treat migraines3, insomnia, depression, and anxiety. It can also help those who have chronic inflammation issues (as a sign of magnesium deficiency is chronic inflammation), and it can be a possible treatment for PMS. Finally, those who are looking for a sports performance supplement may also benefit from increasing magnesium intakes, as the mineral has been found to be effective for helping even the healthiest individuals improve their energy metabolism and performance.

Daily Recommended Allowance of Magnesium

Different people have different daily recommended amounts of magnesium. For men, 400 mg is the main amount, although they can be advised to allow up to 420 mg (ODS). Women are recommended to have between 310 and 360 mg per day, and children’s daily recommended amount increases as they grow older, from about 30 mg per day at infancy to 360 mg for girls and 410 for boys during their teen years. Pregnant and breastfeeding individuals may often see an increased daily recommended amount as well.

  • Men: 400 mg daily
  • Women: 310-360 mg daily
  • Teen boys: 410 mg
  • Teen girls: 360 mg

How to Use Magnesium

Magnesium is often present in a daily multivitamin and mineral supplement, and many people use this as an option for covering all their bases. Still, those who want to take magnesium on its own may do so by taking a pill that contains magnesium, magnesium aspartate, magnesium chloride, magnesium citrate or magnesium lactate (ODS 3).

Magnesium, like any supplement, should not be taken without a healthcare professional’s formal approval. If used incorrectly, it could potentially affect the use of other medications or cause health problems, which is why it is always important to check with your doctor before you start using magnesium and to get their express medical advice on the subject.

Symptoms of Magnesium Deficiency

Magnesium deficiency on its own is not a common occurrence, but many people deal with low magnesium levels (also known as hypomagnesemia). Sometimes, this is because they are not getting their necessary dietary magnesium intakes while other times it could be the product of a behavior or condition (but more on that later).

The National Library of Medicine and the ODS list the common symptoms of hypomagnesemia as

  • Nystagmus (or strange, rapid eye movements)
  • Numbness in the body
  • Nausea
  • Vomiting
  • Loss of appetite
  • Weak muscles
  • Facial tics or spasms
  • Cramps
  • Fatigue
  • Seizures
  • Arrhythmic heartbeat
  • Changes in personality

Some of these are associated with more severe magnesium deficiency than others. For example, seizures, numbness, heart rhythm changes and personality changes are all associated with a severe case of hypomagnesemia.

Who Is at Risk of a Magnesium Deficiency?

Many individuals, especially in the United States, are not getting the amount of magnesium they should be getting in their diets. Usually, the signs of magnesium deficiency are not as pronounced when this occurs, however, because the body is able to store the mineral for long periods of time without replenishment (University of Florida).

Still, there are some behaviors and conditions that can make an individual more likely to experience losses of magnesium. These include

  • Frequent alcohol abuse
  • Kidney disease
  • Vomiting or diarrhea that lasts for long periods of time
  • Diuretic drug use
  • Hypercalcemia (or having a high level of blood calcium)
  • IBS or celiac disease
  • Metabolic syndrome
  • Old age

Zinc (15 mg)

zinc

Your body is a vessel. What you put into it is what you get out. Eating right, exercise and routine check-ups are important to make sure you are healthy and in the best possible shape. 

Those that take care of their body will see the benefits in both the short term and the long term. A healthy lifestyle will help you maintain a healthy weight which in turn reduces your risk of developing certain diseases and illnesses such as obesity, diabetes, and certain cancers.

Energy is something everyone wishes they had more of. The solution may be as simple as adopting a healthier lifestyle.  

A healthy lifestyle goes hand-in-hand with increased energy. Feeling good on the inside leads to feeling good on the outside and a higher level of confidence in your day to day life.

Micronutrients Versus Macronutrients

The human body is a very complex organism, containing thousands of parts that work together to make the body as a whole function properly. Nutrition is the fuel that allows your body to carry out life's many processes. Your body needs a wide array of nutrients to meet all of its needs. This includes both macronutrients and micronutrients. Macronutrients, as most people are aware, constitute proteins, carbohydrates, and fats that the body needs in large amounts. The body needs micronutrients in much smaller quantities as compared to macronutrients.

Vitamins and minerals make up the category known as micronutrients. Although many of these are needed in small amounts, they are still considered very important to your overall well being.  Zinc is one such essential mineral needed by the body in trace amounts to aid in very important life processes.

What Is Zinc?

Most likely you have heard of zinc in some form or fashion, but what is zinc and why is it so important? 

Zinc is an essential trace element the body needs to carry out certain processes, especially at a cellular level. It is found in every type of tissue and organ in the body. 

The majority of zinc is found in the skeletal system and the surrounding muscle tissue. In general, this mineral is known for its role in the function of the immune system as well as to aid in smell and taste. 

On a cellular level, zinc aids in cell division and growth. Over 100 enzymes are acted on by this essential nutrient making it necessary to the body's metabolic processes. Zinc is transported by proteins and is known as the second most common transition metal in the human body.

Although zinc is present in all of the body's organs, tissues and fluids, your body is not able to store or manufacture zinc on its own. This means thatyou must consume zinc in your diet daily in order to meet the needed requirements.

Health Benefits of Zinc

Zinc is essential for physiological processes in the body associated with growth, immune function, reproduction, and growth. 

High cholesterol is a very common issue among individuals in the United States. Studies have shown zinc supplements increase the levels of HDL cholesterol, also known as "good" cholesterol while lowering LDL, also known as "bad" cholesterol. 

Depending on your doctor's recommendations, naturally lowering your cholesterol might give you the ability to cut back on or discontinue cholesterol medications.

Research suggests that maintaining recommended levels of zinc in the body can help the body recover from certain illnesses, such as the common cold, quicker and promote the healing of wounds by helping the blood to clot faster. 

The reason for this can be attributed to the fact that zinc promotes cell growth, which is needed to heal wounds. Studies show zinc lozenges are effective for reducing the duration of the common cold by one day, if taken within 24 hours of the first symptoms.

There is also evidence that zinc can help with age-related macular degeneration, by slowing the progression of the disease. Not only does zinc provide health but benefits, but in fact, a deficiency in zinc can lead to an increased risk of contracting an illness.

How to Use Zinc

The amount of zinc needed by the body is based on age, gender, and whether or not you are pregnant or breastfeeding. The zinc needs of adults stay consistent, but children grow at a faster rate, which means their needs change more frequently.

Men need a slightly higher amount of zinc than women. According to the National Institutes of Health daily zinc recommendations are as follows:

  • Adult Women: 8 mg per day
  • Adult Men: 11 mg per day

Children are smaller in size and therefore do not require zinc in as high of dosages as adults do. The National Institutes of Health recommends:

  • 0-6 months: receive 2 mg per day
  • 7-12 months: receive 3 mg per day
  • 1-3 years receive: 5 mg per day
  • 4-8 years receive: 8 mg per day
  • Girls 14-18 years: receive 9 mg per day
  • Boys 14-18 years: receive 11 mg per day
  • Girls 19 years and older: receive 8 mg per day
  • Boys 19 years and older: receive 11 mg per day

Women who are pregnant or breastfeeding typically have higher nutrient requirements in general than women who are not pregnant. Pregnant women will need to consume higher amounts of zinc to support their growing baby. Most pregnant and breastfeeding women need between 11-13 milligrams of zinc per day.

You should always consult with your doctor or child's pediatrician to discuss your zinc intake and the need for a change in diet or addition of zinc supplements.

How Can I Get the Necessary Levels of Zinc?

As mentioned earlier, your body is not able to produce zinc on its own. This means it must be consumed daily through your diet in the recommended amounts. 

Oftentimes, eating a well-balanced diet will ensure you receive the required amount of zinc. Everyone leads busy lives and it is hard to eat healthy all of the time. This is where supplements come in. If your diet does not give you the necessary zinc, taking a supplement will fill in the nutritional gap.

According to the Mayo Clinic, it is recommended to take zinc supplements a couple of hours before eating a meal. There are cases where supplements can cause an upset stomach. If this is the case, take zinc with your meal to prevent the occurrence of unwanted upset stomachs.

Symptoms of Zinc Deficiency

Studies suggest there are approximately 2 billion people worldwide who suffer from either mild or severe cases of a zinc deficiency. It is estimated that up to 12 percent of the population in the United States are at risk for zinc deficiency. This is considered a high percentage for a developed country whose population has access to adequate food sources.

A deficiency in zinc can either occur one of two ways. The first way is an inherited condition where the body has a reduced ability to absorb zinc properly. The second way is an absence of adequate zinc in the diet. Both of these paths lead to a zinc deficiency that negatively affects your health.

Because zinc is in every organ and tissue in the body, a deficiency affects every part of the body. The brain3, which is the processing unit for the body, can experience mental lethargy, neurosensory disorders, neuropsychiatric disorders, and decreased nerve conduction. Psychological disorders like anorexia have been reported in individuals suffering from a zinc deficiency.4

The reproductive system is adversely affected by a lack of zinc in the diet. Symptoms include3:

  • infertility
  • hypogonadism
  • retarded genital development

Additional symptoms3 include thymic atrophy, skin lesions, slower wound healing, and acrodermatitis.

Although it sounds obvious, it can be difficult to accurately diagnose a zinc deficiency. A blood test is the best way to diagnose a deficiency. Testing the levels of zinc in plasma5 is a common service provided by most laboratories. Other less common methods include:

  • Metabolic Studies
  • Excretion of zinc in urine
  • Zinc Tolerance Test

If you suspect you suffer from a deficiency of zinc, be sure to contact your health care professional for further testing and treatment.

Who is at Risk of a Deficiency?

Everyone needs zinc for their body to be able to carry out certain processes and functions correctly. There are certain groups of people who are at a higher risk for a zinc deficiency than the normal population. These are breastfeeding infants, children, pregnant women, and the elderly.

It is important for infants and children to receive adequate quantities of zinc in their diets. Failure to do so can lead to an increased risk of infection and growth retardation.

Pregnant women are at an increased risk of deficiency due to their need for increased amounts of zinc to support the needs of their growing baby. Studies have shown those carrying a child should take extra care to consume adequate amounts of zinc in their diet.

Studies show that upwards of 30 percent of the elderly population have a zinc deficiency.6 It is natural that certain systems and processes become not less efficient as you age. This is true when it comes to the body's ability to use zinc. The ability to absorb and utilize zinc decreases with age. This statistic puts older individuals at higher risk of developing a deficiency.

What Foods Contain Zinc?

Whether you are a connoisseur of meat or a vegan, there are plenty of foods containing zinc to choose from. Research shows that red meat and poultry are the most common foods that the American population receives their zinc from. Vegetarians and vegans need to be aware that plenty of foods from plants contain zinc, but the zinc from these sources is more difficult to absorb than zinc from animal sources. 

For this reason, it may be necessary to consume extra quantities of these foods in order to receive the recommended amount of zinc. It is worth noting that oysters contain the most zinc per serving compared to any other food. Let's take a look at common food sources containing zinc.

Protein Sources

Protein sources are a very common source of zinc. Most shellfish and red meats contain adequate quantities of this essential nutrient. Common protein sources include:

  • Beef
  • Pork
  • Poultry
  • Lobster
  • Oysters

Dairy Sources

Foods made from dairy products are most notably known as an excellent source of calcium and probiotics, but it is also a good source of zinc. Dairy foods containing zinc include:

  • Yogurt
  • Cheese
  • Milk

Fruit Sources

Fruit makes a great snack and for some even a healthy dessert. There are several fruit sources that are great sources of zinc. These include:

  • Kiwi
  • Bananas
  • Strawberries
  • Raspberries
  • Raisins

Iodine

iodine

Iodine is a miracle mineral for the thyroid gland, however, many people are deficient in this crucial mineral due to the lack of it in their diet. This then results in what is known as hypothyroidism (underactive thyroid gland).

Hypothyroidism causes insensitivity towards GnRH in the pituitary gland, which in turn lowers LH release and slows down testosterone production. This is also one reason why it can mess up the menstrual cycle as well.

Some of the ways that iodine is used in the body is to make and convert thyroid hormone, Thyroxine (T4), into the more powerful, more potent Triiodothyronine (T3).

Men diagnosed with hypothyroidism are much more likely to have low free testosterone levels than men with sufficient thyroid hormone production. And women who are hypothyroid are much more likely to have lower levels of progesterone.

Treatment with exogenous thyroid hormones was shown to, in some cases, more than double testosterone levels. You can see how important the impact is and the interplay between a healthy thyroid and healthy testosterone/progesterone production.

Obviously, iodine is not the only thing needed for the healthy thyroid gland, but it is the most important micronutrient by far in the creation of thyroid hormones, and deficiency is sure to cause massive problems in the endocrine system. Without the presence of iodine, the thyroid gland simply cannot manufacture T3 or T4.

The recommended daily doses according to the national institutes of health is anywhere between 150-290 mcg.

Niacinamide

niacinamide

Niacin also is known as vitamin B3, niacinamide or nicotinic acid, is an essential vitamin that is necessary for many different enzymes to function properly in the human body. 

Niacin is a crucial part of a compound called NADPH (Nicotinamide adenine dinucleotide phosphate). NADPH is a co-factor in many anabolic/androgenic reactions of the body, including both testosterone and dihydrotestosterone production, but also plays a key role in the cascading events leading to thyroid hormone production. 

The mechanisms by which niacin protects the body against oxidative stress can be attributed to its role in the glutathione redox cycle and to other possible roles such as decreasing NADH+H+/NADP+ increasing the NAD+ content in the cell.

Some research has shown that niacin can decrease the amount of SERUM thyroid hormone, however, think about this from a logical perspective. If thyroid hormones are lower in serum, but adding niacin helps the functioning of enzymatic reactions in anabolic pathways, this should mean that the serum thyroid hormone is being taken up at a higher rate. This increase in the uptake of thyroid hormone allows for peripheral conversion to have a higher chance of follow through. 

In simpler terms, less serum thyroid hormone with no decrease in performance in thyroid hormone production means more thyroid hormone getting into cells, thus helping to increase the overall metabolic rate of the cells affected. 

Niacinamide also helps to decrease lipolysis (fat burning). This does not mean that it slows down the rate of fat loss, but instead increases the ability for the cell to preferentially use glucose as a fuel source rather than fatty acids, which is what we want. 

Overall niacinamide is a novel ingredient in this formulation and helps with many different functions of the metabolism on the cellular level.  The recommended daily intake according to the National Institutes of Health is 16-17 mg.

Copper

copper

Copper is an essential mineral that is used in many ways by your body, including the production of hemoglobin and red blood cells, as well as for the proper utilization of iron and oxygen within the blood. 

Because the body uses copper frequently, it cannot store it in sufficient amounts. Regularly eating foods high in copper and overcoming your copper deficiency with a highly bioavailable supplement is recommended.

Copper is needed for healthy thyroid function and  deficiencies in copper are known to cause problems with the thyroid because it works with other minerals like iodine, zinc, and selenium, to properly produce and convert thyroid hormone. 

Copper deficiency is also associated with impaired growth, osteoporosis, and abnormal glucose and cholesterol metabolism.

Copper deficiency is not that common, but there are two very important facts about copper that you should take into consideration. Firstly, almost all kinds of dietary copper are poorly absorbed by the human body (30-40%).

Zinc also tends to depletes copper (and vice versa). Many men like to supplement with zinc because of its possible role in increasing testosterone (as mentioned previously) but are burning through their copper stores because they are forgetting the other piece of the puzzle (optimal ratio of zinc and copper is considered to be between 10:1 and 10:2).

If you supplement with 10 mg’s of zinc per day, then you should also take 1 mg of copper to balance out the zinc-induced copper depletion.

It is important to have all of these minerals in the right forms and dosages in your body for a healthy thyroid, since they all interact with one another and help balance each other out. 

If you are deficient in copper, or any of these other minerals, thyroid imbalance happens. It is that simple. 

It is no wonder that hypothyroidism and hyperthyroidism are so common in the general population right now. It is so easy to be deficient in these things if you do not supplement with them or eat the right foods regularly. 

Some foods that are high in copper that you should be eating regularly are:

Beef liver

1 ounce: 4 milligrams (200 percent DV)

Raisins

1 cup: 0.5 milligram (25 percent DV)

Dried apricots

1 cup: 0.4 milligram (22 percent DV)

Avocado

1 avocado: 0.4 milligram (18 percent DV)

Blackstrap molasses

2 teaspoons: 0.3 milligram (14 percent DV)

Copper is necessary to prevent oxidative damage and lipid peroxidation of PUFAs, which would otherwise indirectly suppress the production and transportation of the thyroid hormones.

Copper (Cu) is not the first thing that comes to mind when we talk about thyroid health but it plays a key role.

If you are supplementing with Thyrite, you are going to be getting a good ratio of zinc to copper. Outside of this, I would base you copper supplementation on the amount of zinc you are currently getting in your diet/supplementation.

Selenium

selenium

Then there is selenium, which is necessary for the normal conversion from the less active (T4) to the most active (T3) thyroid hormone.

Selenium is mostly known for its antioxidant properties, due to the fact that it is a necessary micronutrient in the creation of glutathione (the body’s principal antioxidant compound). Selenium also works in conjunction with vitamin E and C to prevent oxidative damage in the body, and also with iodine to upregulate thyroid function and metabolic rate.

Selenium’s role in thyroid function is twofold. First, with its activity via selenoproteins, it is able to help keep the oxidative stress in the thyroid at a normal to low level so it can function properly. 

The second way that it helps with thyroid function is through helping with the synthesis and function of iodothyronine deiodinases, which are necessary to convert T4 into T3 as mentioned above. 

All in all, without selenium, the thyroid is going to be bombarded with oxidative stress and T4 is not going to be able to be converted into T3, so keeping levels sufficient is a must. 

L-Taurine

taurine

Taurine is an organic acid attached to a sulfur molecule. Taurine was first discovered in 1827 by two German scientists, Friedrich Tiedemann and Leopold Gmelin, who discovered the presence of taurine in the bile of an ox. 

Taurine comprises about 50% of the amino acids in cardiac tissue and when ingested, it significantly increases blood flow and arterial relaxation in human subjects.

It is also extremely important amino-acid for our central nervous system functioning, eyesight, calcium signaling, development and functioning of muscle tissue, and antioxidation.

This also explains why it has been associated with increases in exercise capacity, and increases in subjective well-being. 

Taurine is an antioxidative amino acid that is commonly found in bile, the large intestine, heart, and testicles. Mother’s milk is also high in taurine.

When it comes to health benefits, taurine has many. It can help the body to take in and utilize minerals, balance electrolytes, raise testosterone levels, and improve liver health.

Taurine also has the ability to increase dopamine levels in the brain allowing it to reduce serotonin and prolactin. This is favorable for thyroid function as serotonin and prolactin are antagonistic to optimal thyroid performance.

In actual studies examining taurine intake and thyroid function, it has been seen that lower platelet levels of taurine strongly correlate with hypothyroidism.

Taurine also prevents thyroid damage and T3 & T4 suppression caused by pesticide and lead intake (possibly due to its antioxidant effects).

When looking to supplement with taurine doses in the 150-2000 mg range are shown to be the safest and most effective for long term use. 

L-Tyrosine

tyrosine

Tyrosine is an amino acid that was first discovered in 1846 by the German chemist  Justus von Liebig. 

In the body ,tyrosine is a precursor to dopamine and noradrenaline, some of the benefits that are associated with tyrosine are possible increases in the health of the thyroid, increased resistance to stress, and increases in cognition and memory. 

This is mostly due to tyrosine's effect on stress hormones, especially epinephrine/norepinephrine. It has been shown that it can attenuate the effects of this hormone, allowing it to rise, but then allowing the time being exposed to it to go down. 

Tyrosine has also been shown to have a decent effect on cognition, allowing it to be good for staving off age related cognitive decline.

Some of the best foods that are most dense in tyrosine are cottage cheese, egg whites, and turkey. 

When looking to supplement with tyrosine, there are two forms, regular tyrosine and l-tyrosine, with the L simply meaning that the amino acid is in its free form. Doses before an acute stressor such as a workout are usually within the 500-1000 mg range. 

How to Maximize Results While Taking Thyrite

thyrite

Thyrite is an extremely potent product and works for most people without any kind of changes to their life other than adding in the supplement. However, there are some things that you can do to make Thyrite work even better for you!

  • Combine it with The Thermo Diet - Without a good diet, supplements can only do so much good, but when you support your body properly with the right fuel, then the supplements you use can work wonders.  
  • Be consistent - Many people do not see results because they are simply not consistent with taking the supplement. The more consistent you are, the better your results will be!
  • Exercise - Exercise is crucial for a healthy body, and is a key component for having a healthy circulatory system. Resistance training and walking specifically have been shown in research to be the most beneficial in the long term for an optimal functioning body. 
  • Get enough sleep - Sleep is crucial for the body to be able to heal and function at its best. Be sure to get 7-9 hours a night to allow for your body to be fully rejuvenated. 
  • Stack it with Redwood - The ingredients in Redwood and Thyrite work amazing together and many customers cannot go a day without taking them both together as it makes them feel absolutely amazing. 
  • Take the Master Your T Course- From the testosterone expert himself, Mr. Christopher Walker has developed an easy to understand and in depth course on all things testosterone. From the supplements that you should be taking, to the types of foods you can be eating, even to the types of exercises we can do! This course can only be found inside of UMZU fit, UMZU's educational platform with all things health and wellness related. If you want to check it out, you can find it here.

Who Benefits the Most from Thyrite?

who benefits from thyrite

Thyrite is approved for adults 18 years and older. It is perfect for anyone looking to improve the health of their thyroid. If you want to increase energy levels, improve focus, strengthen your memory, and help lower stress levels, then you are a great candidate for Thyrite.

Not sure if this applies to you? Ask yourself if you feel brain fog, unfocused, or passively watching life pass you by? Do you feel as if you do not have enough energy to give to both your career and your family? Do little inconveniences give you anxiety or increase your stress levels? Is your digestion irregular or difficult? If you answered yes to any or all of these questions, then Thyrite is for you.

If you are worried about negative side effects, there is no need for alarm. UMZU uses only natural, safe, and clinically researched ingredients in Thyrite. This means there usually are not any negative side effects associated with taking Thyrite. Even if you are taking medications, Thyrite should not interfere with the effectiveness of these medications, nor should it cause a negative interaction. However, we always recommend that you consult your healthcare provider if you do have concerns before you take Thyrite.

Commonly Asked Questions about Thyrite

Everybody is different, so sometimes what works for most people may not work as well for you.  

Particularly if you have a pre-existing medical condition, you may have some challenges when you add a potent supplement to your regimen.

If you are taking a prescription drug, we strongly recommend that you consult your prescribing medical professional before introducing a new supplement.  

We cannot tell you how a drug might interact with a supplement, beyond saying that sometimes the drug or your underlying condition contraindicate the use of one or more ingredients in a supplement, and it is important to consult your prescribing physician to make sure everything will work well together to support your health.

Another thing to consider is your overall sensitivity to foods and supplements, as well as your body weight.  If you know that you are quite sensitive or you are petite, start out slowly with a lower dose and work up to our recommended serving size, paying attention to how you feel, and dial it back if you find that your body is not tolerating the ‘whole enchilada’ – maybe you are happiest with half an enchilada.  

Know that efficacy is proven at the recommended serving size, but again, that’s a general rule and you may still be able to experience the benefits with a lower dose!

Our Suggested Use instructions call for 4 capsules, 1 time per day or split up to two times a day with a meal. 

thyrite

References 

Copper

  • For males, levels of Zn were associated with decreased levels of FT4 and TT4, and levels of Cu were associated with increased levels of FT4 and TT4. For females, levels of Cu were associated with increased levels of TT3 and TT4. (link)
  •  The results of this study suggest that the metabolism of zinc, copper, manganese, and selenium is abnormal in thyroid diseases. (link)
  • Serum T4 response to TRH was reduced in the copper-deficient as compared to the adequate rats at all time intervals. (Link)
  • However, copper balance is important particularly in relationship to other nutrients. Just as much consideration should be given to the possibility of copper deficiency as to copper toxicity. (Link)
  • Taken together, these results indicate that the intracellular level of redox-active copper is crucial for Pax-8 and TPO expression and for proliferation of thyroid follicular cells. (Link)

Magnesium

  • In rats fed a magnesium-deficient diet, there was slight but statistically significant (P < 0.05) increase in thyroid size when expressed as milligrams of thyroid per 100 gm of body weight (link)
  •  impaired parathyroid function, characterized by undetectable or low serum iPTH, is present in most infants with neonatal hypocalcemia.Depressed plasma Mg is frequently present in hypocalcemic infants (link)
  • Plasma levels of ionised calcium and magnesium were measured in patients with thyroid disease and in controls. Plasma-ionised calcium was significantly raised in thyrotoxic patients, but plasma-total-calcium was normal. Both plasma-ionised magnesium and total magnesium levels were significantly lowered. (link)
  • Plasma and RBC Mg concentrations were low in half of the hyperthyroid subjects, but mean values were not significantly different from controls. Urinary excretion and clearance of Mg were lower in hypothyroid subjects,(link)

Selenium

  • Inadequate supply of the essential trace element selenium (Se) has been associated with predisposition for, or manifestation of, various human diseases such as Keshan and Kashin–Beck disease, cancer, impaired immune function, neurodegenerative and age-related disorders and disturbances of the thyroid hormone axis. (link)
  •  The Se content in endocrine tissues (thyroid, adrenals, pituitary, testes, ovary) is higher than in many other organs. Nutritional Se depletion results in retention, whereas Se repletion is followed by a rapid accumulation of Se in endocrine tissues, reproductive organs, and the brain (link)
  • During pregnancy and the postpartum period, 77 TPOAb(+) women received selenomethionine 200 μg/d (group S1), PPTD and permanent hypothyroidism were significantly lower in group S1 (link)
  • Recently, however, type I iodothyronine 5′-deiodinase has also been shown to be a selenium-containing enzyme. This explains the impairment of thyroid hormone metabolism caused by selenium deficiency in animals with a normal vitamin E status. Since iodothyronine 5′-deiodinases are essential for the production of the active thyroid hormone (link)
  • Thus, selenium-deficient rats have low tissue deiodinase activities and abnormal thyroid hormone metabolism. (link)
  • Three different selenium-dependent iodothyronine deiodinases (types I, II, and III) can both activate and inactivate thyroid hormones, making selenium an essential micronutrient for normal development, growth, and metabolism. Furthermore, selenium is found as selenocysteine in the catalytic center of enzymes protecting the thyroid from free radicals damage (link)
  • Low-dose selenium supplementation in pregnant women with mild-to-moderate deficiency had no effect on TPO-Ab concentration, but tended to change thyroid function in Thy-Ab+ve women. (link)
  • Delodinase type I which has been shown to be a seleno‐enzyme could account for the changes in thyroid hormones In our subjects. Our data show that selenium plays a definite role in thyroid hormone metabolism In humans. Selenium (Link)
  • We concluded that reduced peripheral T4 conversion is related to impaired Se status in the elderly. (link)

Zinc

  • Zinc sulfate supplementation improves thyroid function in hypozincemic down children (link)
  • . Zinc deficiency lowers T3 more than comparable caloric restriction; this suggests that zinc deficiency may impair extrathyroidal production of T3. (link)
  •  Zinc supplementation appeared to have a favorable effect on thyroid hormone levels, particularly total T3, and RMR (link)
  • Zinc Affects the Metabolism of Thyroid Hormones in Children with Down's Syndrome: Normalization of Thyroid Stimulating Hormone and of Reversal Triiodothyronine Plasmic Levels by Dietary Zinc Supplementation (link)
  • Zn may play a role in thyroid hormone metabolism in low T3 patients and may in part contribute to conversion of T4 to T3 in humans. (link)
  • The activity of hepatic type I 5′deiodinase was decreased by 67% by zinc deficiency and by 47% by selenium deficiency compared to adequate controls. The study data show that both zinc and selenium deficiency affect the metabolism of thyroid hormones. (link)
  •  The results suggest that low zinc intakes may be associated with decreases in BMR. In addition, decreases in thyroid hormone levels and alterations in protein utilization may occur. (link)
  • Single and multiple deficiencies of Se, Zn and I have distinct effects on thyroid metabolism and structure. (link)
  • The T3 receptor is thought to require zinc to adopt its biologically active conformation. Some of the effects of zinc deficiency, therefore, may be due to loss of zinc from the T3 receptor and impairment of T3action. (link)

Iodine 

  • Iodine is most important as a component of the hormones, thyroxine and 3,3′,5-tri-iodothyronine (T 3 ) and iodine deficiency may affect approximately one billion people throughout the world.  (link)
  • Variations in population iodine intake do not affect risk for Graves' disease or thyroid cancer, but correction of iodine deficiency might shift thyroid cancer subtypes toward less malignant forms. Thus, optimisation of population iodine intake is an important component of preventive health care to reduce the prevalence of thyroid disorders. (link)
  • There are a number of thyroid disorders in this previously iodine-deficient region. Further studies are required to investigate the change of thyroid disorders during iodine supplementation programs. (link)
  • Small amounts of supplemental iodine cause slight but significant changes in thyroid function in predisposed individuals. (link)
  • Hence, the iodine intake should be brought to a level at which iodine deficiency disorders are avoided but not higher. (link)
  • The smaller iodine supplements of 500 and 250 μg daily, quantities that may easily be achieved under normal conditions, did not, however, affect thyroid function. (link)

L-tyrosine

  • L-tyrosine. The thyroid gland combines tyrosine and iodine to make thyroid hormone. (link)
  • Conversely, the levels of tyrosine in plasma of hypothyroid subjects arc diminished (link)
  • These findings indicate that the neuroendocrine network plays an important role in chronic stress, and that L-tyrosine supplementation has therapeutic effects. (link)

L-Taurine

  • These findings suggest that taurine supplementation may play a protective role against the increased oxidative stress resulting from hypothyroidism. (link)
  • Taurine alleviated the perturbations in thyroid function and improved thyroid gland histoarchitecture. The beneficial effects of taurine may be attributed to its ability to protect the body from toxicity and oxidative stress. Taurine may be useful for prophylaxis against disruptions in thyroid function in animals that are exposed to environmental chlorpyrifos and lead.(link)
  • Taurine (2-aminoethanesulfonic acid), well known for its role in bile salt synthesis, is also involved in a number of crucial physiological processes including modulation of calcium flux and neuronal excitability, osmoregulation, detoxification, and membrane stabilization. (link)
  • Taurine Ameliorates Renal Oxidative Damage and Thyroid Dysfunction in Rats Chronically Exposed to Fluoride (link)
  • In summary, it was suggested that taurine may have a regulatory effect on diabetes-induced changes in the gonadal-hormone levels by inhibiting hypothalamic–pituitary–gonadal axis and thyroid dysfunctions in the diabetic male rats. (link)

Ashwagandha

  • These findings reveal that the ashwagandha root extract stimulates thyroidal activity and also enhances the antiperoxidation of hepatic tissue. (link)
  •  It appears that these plant extracts are capable of stimulating thyroid function in female mice. (link)
  • Nonetheless, the thyroid enhancing properties of ASW may also represent a clinical opportunity for the treatment of subclinical hypothyroidism (link)
  •  Treatment with ashwagandha may be beneficial for normalizing thyroid indices in subclinical hypothyroid patients. (link)
  •  The herbal preparations used in both systems of medicine have been found to be effective in managing hypothyroidism. (link)

Niacinamide

  • The mechanisms by which niacin protects the body against oxidative stress can be attributed to the glutathione redox cycle and also to other possible roles such as decreasing NADH+H+/NADP+ ratio as well as increasing the NAD+ content. (link)

Forskolin

  • We conclude that forskolin is a useful activator of thyroid adenylate cyclase both in vitro and in intact tissue, which will be useful in elucidating the coupling process of the adenylate cyclase system and in differentiating cAMP-mediated from other forms of activation of the thyroid (link)
  • forskolin is a stimulator of cAMP. The results indicate that cAMP probably activates the onset of both morphological and physiological maturation in the fetal rat thyroid.(link)
  • In other respects forskolin seems to induce absolute and relative secretion of T3 and T4 very similar to those obtained by cAMP and TSH. (link)