Rutaecarpine

Rutaecarpine has long been used in traditional Chinese medicine to counteract the effects of caffeine, aid digestion problems, counter infection and maintain body weight.It is a plant native to China and Korea that grows berries known as "fruits of evodia," or evodia fructae. Rutaecarpine is a compound that is isolated from the berries produced by the evodia rutaecarpa plant.Rutaecarpine is also referred to as evodia, evodia extract, evodiae fructus, evodia fruit, and evodia rutaecarpa.

The Traditional Benefits of Rutaecarpine

Rutaecarpine is most notable known for helping to improve sleep and thus improve recovery for exercise performance

What is Rutaecarpine Used For?

Rutaecarpine may have numerous benefits to the body, including the following: Weakens the Effects of Caffeine, May Help Kill Off Cancer Cells, Reduces Inflammation, May Help Burn Body Fat.

Benefits of Rutaecarpine

While the research on the effects of rutaecarpine on the human body is still somewhat limited, it is suggested that the chemical has a number of potential benefits, including the following:, Weakens the effects of caffeine. Rutaecarpine has been shown to metabolize caffeine, causing it to be excreted from the body quickly and reducing its effects on the body(1). With quick elimination of caffeine, any unpleasant side effects of caffeine can subside, including sleeplessness and jitters. May help kill off cancer cells. Some studies(2) suggest that rutaecarpine shows promise as an anti-cancer agent by killing cancer cells and inhibiting the growth of tumor cell lines, particularly for cervical cancer, melanoma and cancer of the thyroid(3). Reduces inflammation. Rutaecarpine has long been used for its anti-inflammatory properties thanks to the actions of certain constituents of the evodia rutaecarpa plant(4). May burn body fat. Rutaecarpine has been investigated as a fat burner(5) and therefore has been touted as a potentially effective weight loss agent. in animal studies, it appears to make subjects feel hotter and expends heat more efficiently, which has a fat-burning effect. Other potential benefits of rutaecarpine may include the following, though evidence to support such claims is very limited: Diarrhea, Nausea, Vomiting, Lack of Menstruation, Stomach Ulcers, Gastroesophageal Reflux Disease, And Fluid Retention.

Supplementing with Rutaecarpine

Certain individuals should not take rutaecarpine, including pregnant or breastfeeding women, as there is insufficient information showing whether or not the chemical is safe for both mother and baby. Further, those who are scheduled for surgery in the near future should not take rutaecarpine because of its link to slowed blood clotting. There may be a concern that rutaecarpine could increase the risk of bleeding during and after surgery. Currently, there isn't enough scientific data on rutaecarpine to determine an appropriate dose for the chemical. That said, dosing should be based on a number of factors including the user's: Age, Weight, Health, Use of Medications, Presence of Illness. It's also important to follow manufacturers' suggestions when dosing, so be sure to follow specific directions on product labels and always consult with a doctor or pharmacist before using rutaecarpine or any other natural supplement.

Is Rutaecarpine Healthy?

There may be some evidence to suggest that rutaecarpine can help reduce the jittery effects of caffeine, help with weight loss, and aid with digestive issues. But the science behind the chemical is limited to just animal studies.More human studies are needed to solidify rutaecarpine benefits on the human body. As with any other supplement or herbal product, it's important to consult with a physician or health care practitioner first.

Citations and Sources

1. Noh K, Seo Y, Lee S, et al. Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats. Arch Pharm Res. 2011;34(1):119-125. https://www.ncbi.nlm.nih.gov/pubmed/21468923. 2. Zhang Y, Wu L, Tashiro S, Onodera S, Ikejima T. Evodiamine induces tumor cell death through different pathways: apoptosis and necrosis. Acta Pharmacol Sin. 2004;25(1):83-89. https://www.ncbi.nlm.nih.gov/pubmed/14704127. 3. Chen M, Yu C, Wang S, et al. Anti-proliferative effects of evodiamine on human thyroid cancer cell line ARO. J Cell Biochem. 2010;110(6):1495-1503. https://www.ncbi.nlm.nih.gov/pubmed/20503248. 4. Choi Y, Shin E, Kim Y, Cai X, Lee J, Kim H. Anti-inflammatory principles from the fruits of Evodia rutaecarpa and their cellular action mechanisms. Arch Pharm Res. 2006;29(4):293-297. https://www.ncbi.nlm.nih.gov/pubmed/16681034. 5. Bak E, Park H, Kim J, Kim J, Yoo Y, Cha J. Inhibitory effect of evodiamine alone and in combination with rosiglitazone on in vitro adipocyte differentiation and in vivo obesity related to diabetes. Int J Obes (Lond). 2010;34(2):250-260. https://www.ncbi.nlm.nih.gov/pubmed/19859078.

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