Collagen

Collagen is the most abundant protein in the human body. It makes up 25-35 percent(1) of all the protein in human tissues. The structure of collagen is made of rope-like strands of amino acids that tie together in a triple helix. The most common amino acids in collagen are proline, glycine, glutamine and arginine. Ligaments, tendons and skin all contain a significant amount of collagen and collagen is often referred to as the body's scaffolding because it gives tissues structure. When humans age, their natural collagen production diminishes. The decline can be as quick as one percent per year(2). Under a microscope, collagen fibers in aging skin look sparser and less organized than the fibers in younger skin.

The traditional Benefits of Collagen

When humans consume collagen, enzymes in the stomach break down the molecules into smaller chains of proteins. Some collagen supplements, called hydrolyzed collagen, come already broken down for better bioavailability. Collagen supplements may improve gut health, ease joint pain, strengthen hair, strengthen nails and improve skin health.

What is Collagen Used For?

Collagen may have numerous benefits to the body, including the following: Improves Skin Health and Elasticity, Fortifies Joints, Boosts Gut Health, Increases Muscle Mass, Strengthens Hair and Nails.

Benefits of Collagen

Taking a collagen supplement helps to replenish collagen that declines with age. Collagen supplements may improve gut, joint, skin, hair and nail health.Skin Health Research(2) shows that taking collagen can improve skin health by reducing dryness and wrinkles. Taking collagen may stimulate the body to produce collagen. Supplementation may also stimulate the body to produce elastin, which gives skin its ability to retain its shape even when stretched. One study(3) found that 2.5-5g of daily collagen supplementation improved skin elasticity and moisture in women over the age of 35. However, the study didn't reach statistical significance. Another study by the same researchers(3) found women had a decline in wrinkles after eight weeks. Joint Health Collagen supplementation may also improve joint health(4) and reduce the likelihood of developing osteoarthritis. Type 2 collagen is most prominent in cartilage tissue. Supplements with type II collagen may have the greatest effect on joint health. One study(5) found that patients with knee osteoarthritis treated with type 2 collagen showed significant enhancements in daily activities such as walking up stairs and sleeping without pain compared to patients who took a placebo.Gut Health Collagen gives connective tissue around the digestive system structure. Research6 shows that people with inflammatory bowel disease have lower levels of serum collagen than healthy individuals. However, there's no specific research showing that collagen supplementation will improve gut health. Muscle Mass Collagen(7) is also responsible for giving muscles structure. Up to 10 percent of muscle tissue is made from collagen. Research(8) shows that collagen may reduce age-related muscle decline in elderly people. Hair and Nail Health Taking a collagen supplementation may help individuals looking to grow out their nails(9). When nails are brittle, they break easily. However, a collagen supplement may increase nail strength and reduce the frequency of breaks. Hair can also become brittle when collagen levels are low. Taking a collagen supplement may also increase hair strength(10).

Types of Collagen

There are at least 28 types of collagen but type I, II and III make up more than 80 percent percent of the collagen in the human body. Type I collagenType I collagen is the most abundant and strongest type of collagen. It’s the main structural component in tendons, ligaments, organs and skin. It provides structure to bones and teeth as well as gives skin its elasticity. It makes up about 80 percent of the collagen in human skin. Type II collagenType II collagen is the main structural component in cartilage found on the surface of joints. It gives cartilage its shock absorbing ability and supplementation can reduce age-related joint pain. This type of collagen also gives structure to eyes. Type III collagen Type III collagen gives skin its firmness. It also forms the structure of blood vessels and the human heart. Type I and type III collagen are more similar to each other than to type II collagen. These fibers are often found in the same places in the body. Hydrolyzed collagenSome collagen supplements are hydrolyzed, which means the strands of collagen peptides are broken into smaller particles to increase bioavailability. Any type of collagen can be hydrolyzed.

How to Use Collagen

Collagen supplements come in several different forms. Each form of collagen protein has pros and cons. Collagen PowderMost collagen powders come in powdered form. Collagen powders easily dissolve into smoothies or other liquids and are relatively tasteless. Some collagen powders may be flavored and can be mixed with other protein powders. Collagen powders can also be heated and mixed into soups or broths. Collagen CapsulesCollagen products that come in capsule form allow for quick supplementation for people who don't have time to make a smoothie. Capsules are easier to transport and can be taken by themselves. Liquid Collagen Liquid collagen is an alternative to collagen powder for people who plan to mix it with smoothies or in soups. Collagen Injections Some people opt for collagen injections to achieve younger looking skin and to reduce wrinkles. However, collagen injections come with the risk of allergic reaction or bruising and redness at the site of injection. There's no DRA for collagen. Humans can produce collagen by breaking down dietary protein and resembling the amino acids in that protein into collagen. The biggest concern with collagen supplementation is the risk of heavy metal poisoning from contaminants found in the supplement. However, the risk of heavy metal poison is relatively low and can be mitigated by choosing high quality collagen products. To maximize the benefits from taking a collagen supplement, one should take at least five grams per day. Taking 10 grams of hydrolyzed collagen may have benefits for skin health and joint health. Athletes or people with brittle hair and nails can take up to 15 grams per day. Many brands of powdered collagen supplements come with a 10-gram scoop.

Foods that Contain Collagen

The most common sources of collagen in the human diet are high-protein animal products. Bone broth is one of the most concentrated sources of collagen. Gelatin is also derived from the collagen found in the bones of animals. Since the body first has to break collagen into individual amino acids, it may be more valuable to eat high protein foods like milk and eggs. Eating a balanced diet that's high in protein should provide enough collagen for healthy individuals. Different sources of collagen provide different amounts of each type of collagen. Here are some of the most common collagen sources. Bovine Collagen Bovine collagen is sourced from the skin, bones and muscles of cows. It provides mostly type 1 and 3 collagen. Chicken Collagen Chicken collagen is highest in type 2 collagen, which the human body can use to build and repair cartilage. Chicken collagen may be most beneficial for people with joint problems.Fish Collagen Fish collagen contains mostly type 1 collagen. Fish collagen benefits joints, skin, organs and blood vessels. Egg Collagen Egg collagen is found in the shells and whites of eggs. It contains mostly type 1 collagen. Egg collagen is the top source of collagen for vegetarians.

Citations and Sources

1. Di L, Sweeney S, Korkko J, Ala-Kokko L, San A. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem. 2002;277(6):4223-4231. [PubMed] 2. Ganceviciene R, Liakou A, Theodoridis A, Makrantonaki E, Zouboulis C. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308-319. [PMC] 3. Proksch E, Segger D, Degwert J, Schunck M, Zague V, Oesser S. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol. 2014;27(1):47-55. [PubMed] 4. Clark K, Sebastianelli W, Flechsenhar K, et al. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes with activity-related joint pain. Curr Med Res Opin. 2008;24(5):1485-1496. [PubMed] 5. Crowley D, Lau F, Sharma P, et al. Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial. Int J Med Sci. 2009;6(6):312-321. [PMC] 6. Koutroubakis I, Petinaki E, Dimoulios P, et al. Serum laminin and collagen IV in inflammatory bowel disease. J Clin Pathol. 2003;56(11):817-820. [PubMed] 7. Gillies A, Lieber R. Structure and Function of the Skeletal Muscle Extracellular Matrix. Muscle Nerve. 2011;44(3):318-331. [PMC] 8. Zdzieblik D, Oesser S, Baumstark M, Gollhofer A, König D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr. 2015;114(8):1237-1245. [PMC] 9. Hexsel D, Zague V, Schunck M, Siega C, Camozzato F, Oesser S. Oral supplementation with specific bioactive collagen peptides improves nail growth and reduces symptoms of brittle nails. J Cosmet Dermatol. 2017;16(4):520-526. [PubMed] 10. Chen P, Cescon M, Bonaldo P. Lack of Collagen VI Promotes Wound-Induced Hair Growth. J Invest Dermatol. 2015;135(10):2358-2367. [PubMed] 11. Stuart J, Townes A, Kang A. Collagen autoimmune arthritis. Annu Rev Immunol. 1984;2:199-218. [PubMed] 12. Varani J, Dame M, Rittie L, et al. Decreased Collagen Production in Chronologically Aged Skin : Roles of Age-Dependent Alteration in Fibroblast Function and Defective Mechanical Stimulation. Am J Pathol. 2006;168(6):1861-1868. [PMC] 13. Danby F. Nutrition and aging skin: sugar and glycation. Clin Dermatol. 2010;28(4):409-411. [PubMed] 14. Knuutinen A, Kokkonen N, Risteli J, et al. Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol. 2002;146(4):588-594. [PubMed] 15. Dhital B, Durlik P, Rathod P, et al. Ultraviolet radiation reduces desmosine cross-links in elastin. Biochem Biophys Rep. 2017;10:172-177. [PMC]

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